General Occlusion of hair follicle infundibulum and then inflammation IL-36 (pro-inflammatory and part of the IL-1 family) may be relevant (IL-36 in hidradenitis suppurativa, Br J Dermatol 208; 178; 761-767) Risk of HS is doubled in smokers compared to non-smokers (Tobacco smoking and hidradenitis suppurativa, Br J Dermatol 208; 178:709-714) History – Age started – ..

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